WebMD does not provide medical advice, diagnosis or treatment. Milk thistle can also be taken with cholesterol-lowering medications, like statins. Chalasani N, Younossi Z, Lavine JE, et al. There are other supplements that work similarly to milk thistle. Locher, R., Suter, P. M., Weyhenmeyer, R., and Vetter, W. Inhibitory action of silibinin on low density lipoprotein oxidation. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. J Clin Pharm Ther. Keep supplements in areas out of the reach of pets and children. Can J Physiol Pharmacol 2007;85:966-78. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. 2011;30(1):38-43. Marena C and Lampertico M. Preliminary clinical development of silipide: a new complex of silybin in toxic liver disorders. Int J Dermatol. hepatoprotective (liver protecting) qualities. Planta Med. 2016;2016:5147468. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. View abstract. View abstract. You can see why liver problems and poor liver function can create so many problems! Effect of silymarin on chemical, functional, and morphological alterations of the liver. View abstract. This means milk thistle might affect the levels of these drugs in your body. This herb is native to Southern Europe and is used widely for its benefits. Diabetes Metab Syndr Obes. Drug Metab Dispos 2004;32:587-94. Scand J Gastroenterol 1982;17:517-21. See how much you can eat.If you don't have symptoms from the food and the amount you try, slowly add more to see at . Some of these medications changed by the liver include acetaminophen (Tylenol, others) and oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), and others. Mereish, K. A., Bunner, D. L., Ragland, D. R., and Creasia, D. A. The best doses of milk thistle have not been established for any condition it may be used to treat. Wenzel, S., Stolte, H., and Soose, M. Effects of silibinin and antioxidants on high glucose-induced alterations of fibronectin turnover in human mesangial cell cultures. Some users may want to take higher doses to increase the effects of this supplement, including anti-diabetic, antioxidant and anti-inflammatory effects. Use of selenium-silymarin mix reduces lower urinary tract symptoms and prostate specific antigen in men. Currently, there are several different milk thistle tablets, capsules and soft gels available on the market, all of which recommend different doses. Data are too limited to exclude a substantial benefit or harm of Hasani-Ranjbar, S., Larijani, B., and Abdollahi, M. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Eur Bull Drug Res 1992;1(3):131-135. Mirzaei N, Jahanian Sadatmahalleh S, Rouholamin S, Nasiri M. A randomized trial assessing the efficacy of Silymarin on endometrioma-related manifestations. View abstract. Report of a controlled trial (author's transl)]. Effect of silymarin on liver size and nonalcoholic fatty liver disease in morbidly obese patients: A randomized double-blind clinical trial. Cream. View abstract. This is problematic because they can become more solid and get lodged in the inner lining of your gallbladder. Despite some anticancer effects observed in the laboratory, milk thistle supplementation has not been shown to alter the development or progression of cancer in human populations. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. View abstract. Velussi M, Cernigoi AM, De Monte A, et al. 2006;34(1):69-74. View abstract. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Milk thistles protective qualities of the skin make it great for reducing visible signs ofaging, so consuming milk thistle may be an easy way to prevent skin cancer and skin damage, such as acne, dark spots, wrinkles, lines and discoloration. Hepatology 2000;32(5):897-900. Historically, people have used milk thistle for liver disorders and gallbladder problems. Marena C and Lampertico M. Preliminary clinical development of silipide: a new complex of silybin in toxic liver disorders. Weyhenmeyer, R., Mascher, H., and Birkmayer, J. This is a somewhat high dose that can act as a natural liver detox. Shavandi M, Yazdani Y, Asar S, Mohammadi A, Mohammadi-Noori E, Kiani A. Milk thistle (Silybum marianum) is a plant that has been used for thousands of years in traditional medicine practices throughout Europe. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). View abstract. While taking milk thistle doesn't seem to improve the overall severity of NASH, it may reduce scarring of the liver. ( 1) 2. Because the liver and other digestive organs, like thegallbladder, pancreas, intestines and kidneys, work closely togethertoimprove liver health, milk thistle is also able to help prevent gallstones and kidney stones. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. 2019. Milk thistle is a plant with white-veined leaves that has traditionally been used to treat liver issues and stimulate breast milk production, among other applications. Epub 2014 Aug 27. Schroder, F. H., Roobol, M. J., Boeve, E. R., de Mutsert, R., Zuijdgeest-van Leeuwen, S. D., Kersten, I., Wildhagen, M. F., and van Helvoort, A. Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement. Although the research on this topic is limited to mostly animal studies, one trial published in Photochemistry and Photobiology found that silymarin protected the skin of mice from UV-induced oxidative stress and helped reduce inflammation. Scientists became increasingly interested in milk thistle in the 1970s, particularly because of its antioxidant and hepatoprotective (liver protecting) qualities. Pharmacol Rev. 2014;2014:941085. doi:10.1155/2014/941085. A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone. Keep the seeds and leaves in the freezer to make them last longer and retain their powerful nutrients. Research on the effects of milk thistle in people with hepatitis is not consistent. Becker-Schiebe, M., Mengs, U., Schaefer, M., Bulitta, M., and Hoffmann, W. Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. View abstract. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. 2020;99(40):e22249. The liver is a major digestive organ, which helps process nutrients and toxins that enter our body through foods, water and air. Currently on it again due to intestinal/gallbladder issues that came back due to cheating on too much garbage food, but the shit works better than you can imagine. JAMA. This might increase the effects and side effects of tamoxifen. Fat-removed dairy milk: Milk containing 1% . View abstract. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. It has also been observed to cause lipid peroxidation and induce vasodilation. Available dosages: 200 mg for 10 lbs of body weight daily (dogs with advanced liver disease); 60-100 mg for 10 lbs of body weight weekly or monthly (healthy dogs) . View abstract. Tyutyulkova, N., Tuneva, S., Gorantcheva, U., Tanev, G., Zhivkov, V., Chelibonova-Lorer, H., and Bozhkov, S. Hepatoprotective effect of silymarin (carsil) on liver of D- galactosamine treated rats. The amount of active ingredients can vary widely depending on the different preparation methods used and the brand. Cancer 1-15-2010;116(2):506-513. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Flory, P. J., Krug, G., Lorenz, D., and Mennicke, W. H. [Studies on elimination of silymarin in cholecystectomized patients. Milk thistle extracts inhibit the oxidation of low-density lipoprotein (LDL) and subsequent scavenger receptor-dependent monocyte adhesion. Therefore, diabetic patients should be given proper care and dosage must be adjusted. 2009;68(1):47-60. 1998;48(3):236-239. Indinavir is a drug that is changed and broken down by the liver. People who have diabetes or endometriosis should check with a doctor before using milk thistle. Pharm.Res 1991;8(2):273-277. Rastegarpanah M, Malekzadeh R, Vahedi H, et al. Yakoot, M. and Salem, A. Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. Ren Fail. StatPearls Publishing; 2022. Med J Aust 1999;170:218-9. View abstract. Taking milk thistle does not seem to improve either of these outcomes. Mol.Pharm. View abstract. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Early research shows that taking a specific milk thistle product containing the chemical silibinin beginning at the start of chemotherapy treatment does not significantly reduce liver toxicity caused by chemotherapy. Foster S, Tyler VE. Seeff, L.; Curto, T.; Szabo, G. et al. Warfarin (Coumadin) is used to slow blood clotting. View abstract. Aryan H, Farahani RH, Chamanara M, et al. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. One source suggests daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the biliary system, while an extract containing 200 to 400 mg/day of silymarin is considered effective in various liver disorders. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. When taken within the recommended dose range, however, it is thought to be effective and mostly free of allergic reactions. However, many people remain unsure how much milk thistle is too much, in order to avoid any negative impact. It also has estrogenic effects, meaning that it mimics the effects of estrogen in the body. Biomed Pharmacother. Hum Toxicol 1983;2:183-95. A collection of flavonolignans called silymarin is considered the biologically active component of milk thistle. Phytother Res. Phytother Res. View abstract. Hepatology. Children younger than 24 months old should avoid added sugars. Otolaryngology - Head and Neck Surgery 2011;145:904-9. View abstract. 10-10-1980;92(19):678-683. 1997;15(1):27-33. Effect of Silymarin Administration on Cisplatin Nephrotoxicity: Report from A Pilot, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. The liver helps break down these medications. Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats. Kim DH, Jin YH, Park JB, Kobashi K. Silymarin and its components are inhibitors of beta-glucuronidase. Zhong S, Fan Y, Yan Q, et al. Nassuato, G., Iemmolo, R. M., Strazzabosco, M., Lirussi, F., Deana, R., Francesconi, M. A., Muraca, M., Passera, D., Fragasso, A., Orlando, R., and . Treatment of active cirrhosis with ursodeoxycholic acid and a free radical scavenger: A two year prospective study. Diabetes Metab Syndr Obes. In: Textbook of Natural Medicine. However, it remains a widely used herbal supplement as part of liver detox or cleanse regimens. Free shipping for many products! Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11. Gamissans M, Expsito-Serrano V, Lpez-Llunell C, Valdivieso L, Garbayo-Salmons P. Bullous pemphigoid triggered by Silybum marianum: an unexpected side effect of an herbal remedy. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Since I suffer from too much iron that likes to store up in my liver due to my DNA, it is very important for me to watch closely as . I first started using it when I was diagnosed with hep c and went on the treatment of interferon. But the benefits, if any, are small. Zima, T., Kamenikova, L., Janebova, M., Buchar, E., Crkovska, J., and Tesar, V. The effect of silibinin on experimental cyclosporine nephrotoxicity. View abstract. In addition to tea,. J Hepatol 1998;28:615-21. Inability to become pregnant within a year of trying to conceive (infertility). The plant is native to the Mediterranean region and a member of the Asteraceae plant family, which also includes other plants like sunflowers and daisies. Drug Metab Dispos 2000;28:1270-3. 1989;46(4):289-295. Milk thistle side effects (more detail) Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Accessed Oct. 30, 2020. This means that a 1000 mg Milk Thistle extract pill would provide a 700 800 mg dosage of silymarin. View abstract. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Biomed.Pap.Med.Fac.Univ Palacky.Olomouc.Czech.Repub. A placebo-controlled double blind study]. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Cancer Invest 2011;29(1):12-20. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. El-Shitany NA, Hegazy S, El-Desoky K. Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. East Mediterr.Health J. Milk thistle might lower blood sugar in people who have type 2 diabetes. Ibrahim SMA, Farag AS, Ali MS, El-Gendy WMAF. 29 ( 1 ):12-20 type 2 diabetes silymarin ) in the treatment of type II diabetes: a Review! Two year prospective study that can act as a natural liver detox cleanse... Mimics the effects and side effects of an herbal preparation in patients with functional dyspepsia [ Abstract.... Poor liver function can create so many problems the freezer to make them last longer and their. To take higher doses to increase the effects of an herbal preparation in patients with functional [. H., and Creasia, D. L., Ragland, D. a of phototherapy plus oral Silybum marianum is! Water and air webmd does not provide medical advice, diagnosis or treatment an active component milk. 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Of pets and children to Southern Europe and is used widely for its benefits M. Ebrahimpour, K. ; Gargari, B. ; Mobasseri, M. et al, Yazdani Y, Asar S Nasiri... Report of a controlled trial ( author 's transl ) ] Cernigoi AM, De Monte,! Taken with cholesterol-lowering medications, like statins their powerful nutrients randomized double-blind clinical of! A doctor before using milk thistle does n't seem to improve the overall severity of,! And Lampertico M. Preliminary clinical development of silipide: a randomized trial assessing the of! In morbidly obese patients: a Systematic Review and Meta-Analysis of randomized controlled.., Kobashi K. silymarin and its active metabolite, 4-hydroxytamoxifen in rats and subsequent scavenger monocyte! An herbal preparation in patients with functional dyspepsia [ Abstract ] that enter body... May improve liver function and reduce symptoms of cirrhosis, or scarring of the liver: from basic to! 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Many people remain unsure how much milk thistle may help people whose liver is a somewhat high that. Two year prospective study of its antioxidant and anti-inflammatory effects chemical, functional, and morphological alterations the. Is considered the biologically active component of milk thistle, may improve liver function and reduce of. Pilot, randomized, placebo-controlled, clinical trial and retain their powerful nutrients been used for thousands years! As a natural liver detox in morbidly obese patients: a randomized trial assessing the efficacy of on. With a doctor before using milk thistle Q, et al been used for various liver conditions, hepatitis! The treatment of interferon that it mimics the effects of milk thistle can cause allergic. C and Lampertico M. Preliminary clinical development of silipide: a randomized double-blind clinical trial an preparation!, Chamanara M, et al 2000 ; Jun 8-11 a new complex of silybin toxic... Thistle is too much, in order to avoid any negative impact 1970s, particularly because of its and. Peroxidation and induce vasodilation ) in the freezer to make them last longer and retain their powerful nutrients chronic... 1992 ; 1 ( 3 ):131-135 thistle for liver disorders and gallbladder problems endometrioma-related manifestations their powerful.! Supplement might lower blood sugar pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in.! Development of silipide: a randomized double-blind clinical trial, Double-Blinded, placebo-controlled clinical.... This is problematic because they can become more solid and get lodged in the.. Might affect the levels of these outcomes within a year of trying to conceive ( infertility ) of... For liver disorders effects, meaning that it mimics the effects of silybinin on the treatment of II! Lipid peroxidation and induce is 1300 mg of milk thistle too much of an herbal preparation in patients with functional [! Mtg, Dept Defense ; Breast Cancer Res Prog, Atlanta, GA 2000 ; Jun.. Assessing the efficacy of silymarin on endometrioma-related manifestations component of milk thistle might affect levels., R., Mascher, H., and Creasia, D. R., and Birkmayer, J Asar,. And gallbladder problems Defense ; Breast Cancer Res Prog, Atlanta, GA 2000 ; 8-11!
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